Kinetic Parameters of Bone Marrow Stem Cells Using In Vivo Suicide by Tritiated Thymidine
نویسندگان
چکیده
The kinetics of colony-forming units (CFU) ment. A computer model helped to explain of the bone marrow in mice were studied the experimental results. The feedback using a method involving the suicide of mechanism seemed to be initiated by the cells in vivo by 3H-TdR or hydroxyurea. depletion of the compartment of maturing After selectively killing cells in S phase, cells. This hypothesis is supported by the the surviving cells traversed S phase in a fact that the CFU response to S-phase cyclic fashion. This enabled the duration cell killing was similar in two strains of of the cycle and of the S phase of CFU mice and was independent of the proporto be measured-8 hr and 4 hr. respection of CFU in S phase. which was approxtively. It was shown that quiescent stem mately 0#{176}/o in the C57B1 and 2O#{176}/o in the cells pass into the proliferative compartC3H mice.
منابع مشابه
Kinetic parameters of bone marrow stem cells using in vivo suicide by tritiated thymidine or by hydroxyurea.
The kinetics of colony-forming units (CFU) ment. A computer model helped to explain of the bone marrow in mice were studied the experimental results. The feedback using a method involving the suicide of mechanism seemed to be initiated by the cells in vivo by 3H-TdR or hydroxyurea. depletion of the compartment of maturing After selectively killing cells in S phase, cells. This hypothesis is sup...
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